Comparison of Systemic and Mucosal Synchronous Immunization with Replicating Single-cycle Adenoviruses and SOSIP Protein HIV-1 Vaccines
Synchronous immunizations of rhesus macaques with gene-based replicating single-cycle adenovirus expressing SIV gag and clade C gp160 envelope, and SOSIP clade C envelope protein vaccine suggest vaccination at the mucosal portal of infection provides better localized protection against incoming SHIV and perhaps HIV-1.