Author

S. Perez

3 papers indexed here

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Open access Sep 2026

Targeting α5-GABAA receptors to restore dopamine system function in a translationally relevant model of perimenopausal psychosis.

BACKGROUND Perimenopause marks a high-risk period for psychiatric instability, often precipitating or exacerbating disorders like schizophrenia. While traditional antipsychotics can be effective, they often worsen vasomotor symptoms and carry side effects that drive high discontinuation rates. We hypothesized that hipp...

Kayla Lilly, D. Sharmin, James M. Cook et al. · Psychopharmacology · 0 citations

Open access Jul 2026

A cortical insula-orbitofrontal circuit drives stress-induced dopamine system dysfunction.

Using in vivo extracellular electrophysiology in rats, this work identifies an IC-OFC-VTA circuit through which stress drives pathological dopamine system activation, providing new mechanistic insight into stress-induced dopamine dysregulation and revealing a novel circuit target for intervention in stress-related psyc...

Olivia J. Yang, Hannah B. Reiley, Angela M. Boley et al. · Molecular Psychiatry · 1 citation

Open access Sep 2026

Enantiomer-specific modulation of GABAA receptors differentially regulates stress-induced dopamine dysregulation.

It is indicated that stereochemical and subunit-selective modulation of GABAA receptors critically determines circuit-level outcomes following stress and reinforce α5-GABAA receptors as a key target for normalizing hippocampal-driven dopamine system dysfunction associated with psychosis-relevant states.

Kayla Lilly, Prithu Mondal, James M. Cook et al. · Psychopharmacology · 1 citation