Behavioral and molecular effects of α2A-adrenergic receptor activation in the triple-hit Lisket rat model of schizophrenia.
Dysregulation of the noradrenergic system has been implicated in the pathophysiology of schizophrenia. Although α2-adenergic receptor (α2-AR) agonists may alleviate positive symptoms, their effects on cognitive and negative symptoms remain controversial. This study aimed to characterize the dose-dependent effects of re...