S. Raffel

IDH3 regulates citrate homeostasis to control metabolic fitness and venetoclax resistance of AML stem cells.

Perturb-seq identifies co-regulated gene programs shaping hematopoietic stem and progenitor cell function

Perturbation-derived co-regulation programs are established as an interpretable framework for linking genetic regulators, cell-biological processes and stem-cell-associated phenotypes by decomposing gene expression data from functional and clinical studies into program activity.

Latent effector T cells mediate immunotherapy responses in the bone marrow microenvironment.

TFiT (tumor-reactive features in T cells), a transcriptional classifier that identifies tumor-reactive T cells and stratifies immunotherapy, but not chemotherapy, response across independent MM and AML cohorts, supporting its specificity for T cell-mediated tumor control.