Study on Synthesis, Antiproliferative Properties, Immunomodulatory Effects, and Anti‐Breast Cancer Activity of New Δ2‐Pyrazoline‐1H‐1,2,3‐Triazole Derivatives
A new series of novel Δ2‐pyrazoline‐1H‐1,2,3‐triazole derivatives synthesized were synthesized and showed a dose‐dependent increase of TIGIT, PD‐1, and LAG‐3 expression in CD3+ T cells, which may enhance responsiveness to checkpoint‐targeted therapies while reflecting complex regulation of T‐cell function.