Author

S. Rahmouni

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Open access Sep 2026

Cell-type specific analyses in blood and gut identify cis-eQTL matching 140 IBD risk loci and entrectinib as repurposing candidate

Genes whose expression is affected, in a consistent manner, by GWAS-identified risk variants and the disease process, constitute preferred drug targets. We herein combine cis-eQTL analysis in 27 sorted blood cell populations and 43 intestinal cell types identified by single cell RNA-Seq in the ileum, colon and rectum,...

H. Perée, Viacheslav A. Petrov, Y. Tokunaga et al. · Nature Communications · 0 citations

Open access Aug 2026

Multi-level aggregation analysis of microbiome composition and host gene expression reveals associations with systemic and local immunity

Multi-level associations are identified between microbiome composition and host gene expression in both intestinal tissues and immune cells, suggesting potential mechanisms by which microbiota shape local and systemic immunity and vice versa.

L. Shagam, Anna Elizarova, Y. Momozawa et al. · Microbiology spectrum · 0 citations