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Clinical trial Open access Sep 2026

Phase 1 study of KHK2455, a long-acting, potent and selective IDO1 inhibitor, in combination with avelumab in patients with locally advanced or metastatic urothelial carcinoma

The favorable safety profile and preliminary efficacy results of KHK2455 in combination with avelumab, along with the translational biomarker findings, warrant further investigation.

Y. Zakharia, B. D. D. de Spéville, R. Morales-Barrera et al. · 0 citations
Sep 2026

Clinical Outcomes of Neuroendocrine Prostate Cancer Treated With Platinum-Based Chemotherapy: A Single-Institution Experience.

INTRODUCTION Neuroendocrine prostate cancer (NEPC) is aggressive with a poor prognosis. Most reported series derive from large databases (e.g., SEER) lacking granular clinical detail. We examined our institution's experience with 58 patients with NEPC. PATIENTS We identified patients with biopsy-proven NEPC treated w...

C. Wee, A. Nizam, M. Ornstein et al. · 0 citations

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