Author

S. Redline

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Clinical trial Open access Aug 2026

Association of tirzepatide with changes in OSA-related measures based on baseline characteristics – post hoc analyses of SURMOUNT-OSA

Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive collapse of the upper airway during sleep. Given that excess adiposity is a known risk factor for OSA, we aimed to descriptively assess the association of tirzepatide, a GIP/GLP-1 receptor agonist, with changes in AHI, hypoxic burden, body w...

Beverly L. Falcon, C. Xie, S. Redline et al. · Journal of Clinical Sleep Me... · 0 citations

Aug 2026

Association of Sleep Variables With Cognitive Performance and the Risk of Dementia in the Sleep and Dementia Consortium.

Sleep composites were not significantly associated with dementia risk, however, longer, more consolidated sleep and stronger slow oscillation-spindle coupling were associated with cognitive performance, and may be useful in guiding further investigations of sleep-brain health relationships.

S. Yiallourou, Crystal D. Wiedner, Qiong Yang et al. · Neurology · 0 citations

Review Aug 2026

Common data element (CDE) and AI-Enabled approaches for clinical data Management: Workshop proceedings from the NIH INCLUDE Project.

OBJECTIVE To evaluate challenges in managing multisite, longitudinal, and multisystem clinical data for Down syndrome (DS) research and identify approaches to improve standardization and reuse. METHODS This report summarizes the outcomes and lessons learned from a NIH workshop convened by the INCLUDE Project to align...

J. Espinosa, Kate Burdekin, J. Auman et al. · Journal of Biomedical Inform... · 0 citations

Open access Aug 2026

Nirmatrelvir-ritonavir targeting viral persistence in post-COVID-19 condition (long COVID) in the USA (RECOVER-VITAL): a randomised, double-blind, placebo-controlled, phase 2 trial.

BACKGROUND Post-acute sequelae of SARS-CoV-2 infection, more commonly known as long COVID, has emerged as a major health problem. The pathogenesis of long COVID is unknown, but among the leading hypotheses is viral persistence. We aimed to investigate whether the use of the SARS-CoV-2 antiviral nirmatrelvir-ritonavir i...

L. Baden, N. Shah, Sean T. H. Liu et al. · Lancet. Infectious Diseases... · 0 citations

Open access Jul 2026

Cross-sectional and Longitudinal Relationships Between Multi-Dimensional Sleep Composites and Cognition in Multi-Ethnic Study of Atherosclerosis (MESA).

EEG-based sleep microstructure and actigraphy-based sleep continuity were associated with cognitive performance cross-sectionally, while actigraphy-based sleep continuity was associated with cognition longitudinally, and these findings support a multidimensional framework for understanding sleep-related risk factors fo...

C. Paquet, Ethan I Powell, Jarvis T Chen et al. · Sleep · 0 citations