For most diseases, whether PRS improves prediction beyond clinical data remains unknown, as existing evidence is concentrated in a handful of conditions with established risk models. Using 900,000 participants from UK Biobank and FinnGen, we developed and validated models for predicting 150 diseases and all-cause morta...
D. Usoltsev, I. Molotkov, N. Kolosov et al.· medRxiv· 0 citations
These findings extend the bradykinin hypothesis of ACEI-induced cough by implicating neurotensin-NTSR1 signalling, pinpoint CYP3A4*22 as a novel functional predictor of dCCB switching with potential for genotype-guided prescribing, and validate medication use trajectories as a framework for pharmacogenetic discovery.
F. Vaura, Kristi Krebs, T. Kiiskinen et al.· European Heart Journal· 0 citations
A genomic meta-analysis of case–control studies of binge-eating behavior and analyses of anorexia nervosa and its subtypes, alongside analyses of AN, identified six BE-associated loci and eight areas that are associated with anorexia nervosa, in people of European ancestry.
Jet D. Termorshuizen, Helena L. Davies, Sang-Hyuck Lee et al.· Nature Mental Health· 1 citation
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