Open access
Aug 2026
A somatic checkpoint through NHR-49/HNF4α governs reproductive investment and longevity in C. elegans
The nuclear hormone receptor NHR-49, a homolog of mammalian PPARα and HNF4α, is a key transcriptional regulator of nutrition sensing and fatty acid metabolism in Caenorhabditis elegans. Here, we examine the role of NHR-49 in reproduction, including oocyte activation and ovulation. Loss of NHR-49 causes inappropriate oo...
Sharada Gopal, A. Chaturbedi, Tej Ramachandrula et al.
· Nature Communications · 0 citations