Author

S. Saber

3 papers indexed here

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Review Sep 2026

The podocyte contactome in lupus nephritis: Current evidence and a framework for disease progression.

Lupus nephritis (LN) is initiated by immune-complex deposition, complement activation, and inflammation, but these mechanisms do not fully explain why some glomerular lesions resolve whereas others progress to podocyte depletion, glomerulosclerosis, and fibrosis. We present a conceptual spatial framework in which grade...

R. S. Hamad, Elsayed A. Elmorsy, A. El-kott et al. · Tissue & Cell · 0 citations

Review Sep 2026

Biophysical and molecular mechanisms of lysosomal mechanoresilience: Membrane tension, TMEM63A, and cellular injury.

Lysosomal membrane failure contributes to cellular injury by disrupting degradation, metabolism, immune signaling, and compartmental integrity, yet the physical principles that determine whether a mechanically loaded lysosome adapts or ruptures remain incompletely resolved. This review integrates biophysical and molecu...

R. S. Hamad, A. El-kott, Sally Negm et al. · Progress in Biophysics and M... · 0 citations

Review Open access Sep 2026

Biophysical and molecular determinants of NCOA4-mediated ferritinophagy at the ferroptosis-inflammation interface: Compartmental iron transport, lipid oxidation, and causal constraints.

Ferritinophagy links molecular recognition of ferritin to the redistribution of redox-active iron across intracellular compartments. This critical narrative review examines nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy as a multiscale process in which NCOA4-FTH1 binding and ferritin condensation govern...

R. S. Hamad, M. Zaghloul, A. Shata et al. · Progress in Biophysics and M... · 0 citations