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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

S. Sagan

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Sep 2026

A nitrone-based in vivo click SHAPE reagent for mapping RNA secondary structure

We report the synthesis and testing of a new reagent for selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE). We report the synthesis and testing of a nitrone acyl imidazole that is capable of labelling RNA (DMImO-AI) for applications including in vivo click SHAPE (icSHAPE). The new reagent has a rea...

Jason D. Josephson, Mariam Serhan, E. Scott et al. · 0 citations
Jul 2026

Transgene Sequence Codon Optimization and Composition Determines Replication Competence of Self-Amplifying RNA.

An underappreciated constraint in saRNA therapeutics is defined and saRNA-specific payload design frameworks that incorporate alphavirus associated compositional biases during transgene sequence optimization are motivated.

N. V. Bathula, Shekinah K V Soriano, Cynthia Huang et al. · 1 citation

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