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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Stephan C. Schürer

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2 papers indexed here

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Jul 2026

Abstract B085: Selective oral STK17A inhibitor UMF814A targets a previously unrecognized dark kinase vulnerability in spliceosome-mutant MDS and AML

Myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML) remain therapeutically challenging, particularly in patients with spliceosome-mutant disease, where effective targeted options are lacking. Mutations in SF3B1, SRSF2, and U2AF1 define a biologically distinct subset associated with aberrant RNA splic...

E. Spinetti, C. C. Pastrana, E. Bravo et al. · 0 citations
Open access Jul 2026

From Ternary Modeling to Predictive PROTAC Design: A Computational Perspective

A Perspective on computational PROTAC methodologies published from 2019 to the present is presented, organizing the field into two complementary streams: constraint-driven, physics-based workflows that assemble and refine ternary complex models by enforcing geometric feasibility and evaluating pose stability using dock...

Joseph M. Schulz, R. Reynolds, S. Schürer · 0 citations

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