Open access
Jul 2026
Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice.
It is found that engraftment of wild-type, but not Grn-deficient, human microglia restore brain-wide progranulin levels, normalize microglial transcriptional states, and ameliorate pathological, functional, and behavioral phenotypes associated with progranulin loss.
H. Davtyan, Sarah Naguib, Y. Voskobiynyk et al.
· Molecular Neurodegeneration · 0 citations