S. Shenoy

Proton Motive Force–Driven Curvature as a Determinant of Cristae Architecture and Bioenergetic Function

Mitochondrial cristae are highly curved invaginations of the inner mitochondrial membrane (IMM) that optimize oxidative phosphorylation (OXPHOS) by concentrating respiratory complexes and adenosine triphosphate (ATP) synthase. The mechanistic relationship between membrane curvature, proton motive force (PMF), and crist...