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Author

S. Showalter

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Open access Aug 2026

Multisite Threonine Phosphorylation in the SPT5 C‑Terminal Region 1 Enables Sequence-Dependent Regulation without Global Structural Remodeling

This work establishes that multisite phosphorylation of the SPT5 CTR1 domain modulates a heterogeneous interaction landscape shaped by sequence context, and emphasizes the nontrivial difference between serine and threonine phosphorylation as a mechanism to regulate disordered protein structure–function relationships.

Rong Hu, E. Usher, Olivia A Fraser et al. · 0 citations

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