Author

S. Siegmund

3 papers indexed here

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Open access Sep 2026

Influence of increased injected activities up 9.0 GBq [177Lu]Lu-PSMA-I&T on absorbed doses to lesions and kidneys

Administration activities of 177Lu-PSMA were chosen cautiously in the treatment of advanced prostate cancer. The primary aim was to investigate the association between increased injected activities, and the calculated absorbed doses (AD). In this single center, retrospective analysis, patients with PSMA-avid metastatic...

Z. Ells, Linus Hempel, J. Ells et al. · EJNMMI Physics · 0 citations

Open access Oct 2026

Long-term effects of [177Lu]Lu-PSMA therapy on the kidneys based on cumulative absorbed dose

177 Lu-PSMA radiopharmaceutical therapy shows favorable clinical responses for metastatic castration-resistant prostate cancer patients but may cause radiation-induced kidney damage due to specific and nonspecific activity accumulation. We evaluated the association between cumulative kidney absorbed doses and...

Z. Ells, Mu-Yu Wu, Linus Hempel et al. · EJNMMI Research · 0 citations

Open access Sep 2026

Fully Automated Segmentation of [18F]FDG and [68Ga]/[18F]PSMA PET/CT Images via Data-Centric Deep Learning.

The purpose of this study was to develop and validate lesion identification in oncologic nuclear imaging (LION), an open-source PET-only tumor segmentation pipeline for [18F]FDG and prostate-specific membrane antigen (PSMA)-targeted PET/CT, and to investigate how training data characteristics influence segmentation per...

M. Pires, S. Gutschmayer, E. Bergalla et al. · Journal of Nuclear Medicine · 1 citation