Author

S. Sivakumar

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Open access Sep 2026

CYLD Mutations, PD-L1 and HPV; A Pan-Cancer Landscape Analysis

Abstract Background CYLD , a tumor suppressor gene encoding a deubiquitinase enzyme, regulates tumorigenesis via NF-κB signaling. CYLD mutations are linked to immune evasion and PD-L1 upregulation, particularly in virus-associated cancers. We evaluated CYLD alterations across cancers and their correlation with PD-L1 ex...

U. Dişel, S. Sisoudiya, S. Sivakumar et al. · Research Square · 0 citations