Development and validation of an RP-HPLC method for cefpodoxime proxetil epimers in human plasma with metabolite characterization, hydrolysis kinetics, and sustainability assessment
To develop and validate a reverse-phase high-performance liquid chromatography (RP-HPLC) bioanalytical method for quantifying cefpodoxime proxetil (CFP) epimers in human plasma and to integrate metabolite synthesis, hydrolysis kinetics, antibacterial evaluation, in silico toxicity prediction, and analytical sustainabil...