Open access
Aug 2026
Sensitive detection of rare HIV-infected cells in the human brain by single-nucleus RNA sequencing
A scalable multi-reference framework for detecting HIV RNA–positive cells in human CNS single-nucleus RNA-seq data is presented and provides large-scale quantitative evidence that microglia represent the dominant and most persistent HIV-infected population in the human brain.
Yuan-Yuan Cai, Nicholas C. Jacobs, Dana Gabuzda et al.
· Virology Journal · 0 citations