S. Sriskandan

Diversity of penicillin-binding protein 2x in Streptococcus pyogenes from England and Wales, 2001 to 2015

Streptococcus pyogenes remains clinically susceptible to β-lactam antibiotics, its first-line treatment. Yet recent reports from the US, Iceland, and Japan have identified isolates with PBP2x (a primary β-lactam target) substitutions that reduced antibiotic susceptibility. To determine whether these PBP2x substitutions...