S. Srivastav

Cell-free DNA fragmentomics and epigenomic profiling in hematologic malignancies: current evidence, translational limitations, and future directions.

Mutation-based liquid biopsy supports diagnosis and disease monitoring in hematologic malignancies, but interpretation of plasma variants may be complicated by clonal hematopoiesis, treatment-related changes, and nonmalignant blood-cell turnover. This structured narrative review evaluates whether cell-free DNA (cfDNA)...

Beyond probiotics and pathobionts: mechanistic roles of enterococcus-derived bioactive components in health and disease.

From beta-cell stress to tertiary lymphoid structure formation: a stage-dependent framework for interpreting type 1 diabetes progression.

A stage-dependent conceptual framework linking beta-cell stress, innate immune activation, and TLS-mediated stabilization of chronic inflammation is presented, providing a rationale for the limited durability of current immune-targeted therapies and identifying experimentally testable hypotheses.