Author

S. Stacchiotti

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Editorial Sep 2026

Growth in oncology clinical trials and decline of independent research: Insights from the 22nd AIFA National Report on clinical trials.

The 22nd National Report on Clinical Trials of Medicinal Products published by the Italian Medicines Agency (AIFA) in July 2026 highlights contrasting trends in Italian clinical research. In 2024, 669 prospective clinical trials were authorized, the highest number recorded in the last three years. Oncology and hemato-o...

C. Cagnazzo, S. Stacchiotti, G. Procopio · Tumori · 0 citations

Open access Aug 2026

Histone deacetylase activity limits the response to EZH2 inhibition-based therapy in epithelioid sarcoma and is targetable by epigenetic combination

Findings identify failure to accumulate H3K27 acetylation as a hallmark of resistance to EZH2 inhibition-based treatment, and show that pharmacological HDAC inhibition can restore this chromatin transition and re-sensitize resistant tumors, providing a rationale for combined epigenetic targeting strategies in INI1-defi...

N. Arrighetti, C. Soffientini, V. Zuco et al. · bioRxiv · 1 citation