Author

S. Strock

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Open access Sep 2026

Molecular and structural basis for replication initiation and strand separation by human mitochondrial DNA polymerase γ

DNA polymerase gamma (Polγ) forms stable complexes with RNA–DNA primer–template substrates, exhibiting greater stability and lower misincorporation than on DNA-primed substrates and has implications for understanding the molecular basis of mitochondrial disease.

Viktoriia Sokolova, Gina Buchel, S. Strock et al. · Nucleic Acids Research · 0 citations