Author

S. Tamura

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Review Open access Sep 2026

First‐Line Lorlatinib in Striatin–Anaplastic Lymphoma Kinase‐Positive Lung Adenocarcinoma: A Case Report and Literature Review

Striatin–anaplastic lymphoma kinase (STRN–ALK) is a rare fusion variant in non‐small cell lung cancer (NSCLC), and the efficacy of first‐line lorlatinib for this subgroup is poorly defined. We report a 45‐year‐old treatment‐naïve male with STRN‐ALK‐positive lung adenocarcinoma and symptomatic brain metastases. Followin...

M. Maebeya, S. Tamura, Takeshi Shono et al. · Respirology Case Reports · 0 citations

Open access Sep 2026

Hypomorphic Lig4 gene mutation in mice predisposes to Th1-skewed intestinal inflammation.

DNA ligase IV (LIG4) is essential for DNA double-strand break (DSB) repair. Hypomorphic LIG4 variants cause LIG4 syndrome, characterized by growth disturbance, increased radiosensitivity, predisposition to malignancies, adaptive immunodeficiency and inflammatory conditions. Most of these manifestations are recapitulate...

Yusuke Yamashita, Hideki Kosako, Takashi Kato et al. · JCI Insight · 0 citations