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S. Tickoo

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Open access Sep 2026

Combined Loss of VHL and TSC1 Drives Clear Cell Renal Cell Carcinoma with Metabolic and Redox Reprogramming that Creates an NRF2 Dependency

Cancer genomics studies have implicated combined loss of VHL and TSC1 as sufficient to initiate clear cell renal cell carcinoma (ccRCC) in humans. Here, we engineered a mouse model with kidney-specific deletion of Vhl and Tsc1. VhlF/FTsc1F/FKsp-Cre+mice developed multifocal renal cell carcinomas starting at 7 weeks of...

Jia-Ning Xu, Xiao-Qing Cheng, O. A. Aboud et al. · 0 citations

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