Author

S. Tokuyama

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Open access Sep 2026

Direct Activation of Orexin Neurons Attenuates Central Post-Stroke Pain in Mice.

BACKGROUND Central post-stroke pain (CPSP) is a refractory complication that occurs after stroke and is classified as central neuropathic pain. Its pathophysiological mechanisms remain unclear and effective pharmacological treatments are limited. Previously, we demonstrated that hypothalamic orexin expression is reduce...

K. Nakamoto, Haruki Yamashita, S. Tokuyama · European Journal of Pain · 0 citations