Author

S. van der Burg

2 papers indexed here

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Open access Oct 2026

Chemotherapy enhances cancer vaccine efficacy and expands stem-like TCF1+CD8+ T cells.

Therapeutic cancer vaccines are increasingly tested in clinical settings alongside standard-of-care treatments that often include chemotherapy, yet whether chemotherapy synergizes with cancer vaccines remains unclear. Here, we tested heterologous prime-boost viral vector vaccines in combination with various chemotherap...

Laurine Noblecourt, Amanda Wicki, Ashwin K. Jainarayanan et al. · Cancer Cell · 0 citations

Clinical trial Open access Aug 2026

IL-2 mutein-engrafted antibody MHS552 selectively expands functional regulatory T cells in nonclinical models and healthy participants

Low-dose interleukin-2 (IL-2) shows potential for treating autoimmune disorders by expanding regulatory T cells (Treg), but therapeutic utility is limited by short half-life and off-target effects. Here, we describe the molecular design, nonclinical development, and first-in-human study of MHS552, an IL-2 mutein-engraf...

Igor Radanović, Michael DiDonato, A. Meijs et al. · Nature Communications · 0 citations