Whole genome analyses have shown that every cell of the body accumulates thousands of genetic changes during a lifetime, with implications for cancer initiation. We have analyzed normal kidney cells from both healthy individuals and patients with the Von Hippel Lindau (VHL) syndrome, which predisposes to kidney cancer....
J. P. Margaria, G. Pipitone, A. Larcher et al.· bioRxiv· 0 citations
Transcription factors (TFs) can access nucleosomes via five distinct modes: gyre-spanning, periodic-binding, dyad-binding, and end-binding modes as well as an oriented binding mode, where the TF binding motif shows orientational preference relative to the nucleosome. Here, we report the first structure of an oriented T...
Tianyi Xiao, C. Crowe-McAuliffe, M. Ochmann et al.· Molecules and Cells· 0 citations
BCL-X
L
is a BCL-2 family anti-apoptotic protein that functions as a targetable dependency in clear cell Renal Cell Carcinoma (ccRCC), the most common form of adult kidney cancer. However, the mechanisms driving this dependence are unclear. Moreover, although significant strides have been made in managing ccRCC,...
Tupa Basuroy, Treg M. Grubb, Ananthan Sadagopan et al.· Cell Death & Disease· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
