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Author

S. Victorelli

2 papers indexed here

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Open access Sep 2026

Blocking PD-L2 prevents senescent cell accumulation and age-related dysfunction.

Senescent cells, which are normally cleared by the immune system but accumulate with age, contribute to multiple disorders including metabolic dysfunction and impaired fitness. While immune checkpoint inhibitors have been well studied in cancer, the role of programmed cell death ligand 2 (PD-L2) in non-cancerous, age-a...

Selim Chaib, Larissa P. G. Langhi Prata, Masayoshi Suda et al. · 0 citations
Open access Jul 2026

Mitochondrial metabolism and epigenetic crosstalk drive SASP

It is shown that mitochondrial metabolism provides a second layer of control that enables execution of the inflammatory programme, and a mechanism that selectively controls the inflammatory output of senescent cells is revealed.

Hélène Martini, Jodie Birch, Francisco D M Marques et al. · 3 citations

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