Author

S. Villeneuve

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Open access Aug 2026

Network-level functional connectivity is associated with longitudinal tau accumulation and amyloid-dependent cognitive decline in preclinical Alzheimer’s disease

Lower static connectivity across multiple large-scale networks was associated with faster longitudinal tau accumulation and, selectively in individuals with elevated amyloid burden, with accelerated cognitive decline, and these associations were not observed for time-varying connectivity.

Mohammadali Javanray, Jonathan Gallego-Rudolf, Y. Yakoub et al. · Research Square · 0 citations

Open access Jul 2026

Parent-of-origin effects in Alzheimer’s liability dissociate neurocognitive and cardiovascular traits in at-risk individuals

Summary Alzheimer’s disease (AD) has a higher prevalence in women than men and is more frequently inherited from mothers than fathers. Yet, while neuroimaging and biomarker studies link maternal family history to stronger AD-related alterations, epidemiological studies suggest that paternal history confers comparable o...

Chloé Savignac, Frédéric St-Onge, S. Villeneuve et al. · Cell Reports Medicine · 0 citations

Open access Aug 2026

CSF complement proteins are associated with early tau pathology and synaptic damage in an asymptomatic population at risk of Alzheimer’s disease

Findings identify complement dysregulation, especially involving C1q, as an early correlate of tau-linked synaptic pathology, and support a role for complement activation in the AD molecular cascade.

J. Loncke, M. Savard, C. Picard et al. · bioRxiv · 0 citations