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S. Villeneuve

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Open access Jul 2026

Sex Differences in the Alzheimer's Brain Age Gap: APOE Îµ4 Plays a Major Role

Sex differences in BAG across the AD continuum were largely explained by APOE {epsilon}4-related acceleration rather than by an independent effect of sex alone, which suggests that females may be more vulnerable to APOE {epsilon}4-associated structural brain aging over time.

R. Rajabli, M. Soltaninejad, S. Villeneuve et al. · medRxiv · 0 citations