Author

S. Walker

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Open access Sep 2026

A tumor-cell MHC-II program is associated with checkpoint-blockade outcomes across stages of bladder cancer

Purpose A minority of patients with bladder cancer derive lasting benefit from immunotherapy, and current biomarkers capture only part of the biology. We evaluated whether tumor-cell MHC class II defines an immune state associated with outcome across disease stages and after PD-1/PD-L1 blockade. Experimental Design We...

J. Bellmunt, Ying-Tian Xie, M. Munoz et al. · bioRxiv · 0 citations

Open access Jul 2026

Buildable linkers: Site-Specific Antibody-Drug Conjugates with Well-Defined Payloads 2308812

The benefits of creating a buildable drug scaffold that’s accommodating for achieving exact payload conjugated at a specific site on Trastuzumab are shown, which will enable all therapeutic antibodies to be conjugated in a uniform manner, accelerating the advancing field of ADC therapeutics.

Lisa Arvidson, Katarina Jovic-Dold, J. Halpern et al. · Journal of Immunology · 0 citations