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S. Weiss

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Open access Mar 2026

SARS-CoV-2 defective viral genomes from distinct genomic regions drive divergent interferon responses

Defective viral genomes (DVGs) are naturally generated during genomic replication of many RNA viruses. When produced early in infection or supplemented at the onset of infection, DVGs can attenuate viral pathogenesis by stimulating IFN responses and antagonizing wild type (WT) virus replication, highlighting their pote...

Justin W. Brennan, Simone Spandau, Jia-Yu Xu et al. · 0 citations
Review Open access Jul 2026

SARS-CoV-2 endoribonucleaseU and ORF6 work synergistically to antagonize innate immune signaling 2327626

The synergistic relationship between nsp15 and ORF6 is essential for efficient SARS-CoV-2 replication and it is hypothesized that since nsp15 functions by reducing dsRNA upstream of ORF6, nsp15 acts as a more potent antagonist leaving little activity for ORF6 to account for.

Nicole R. Bracci, Clayton J. Otter, Nicholas A. Parenti et al. · 0 citations

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