Background Aging is a major nonmodifiable risk factor for cancer, yet age-associated genomic instability, inflammatory activation, and tumor microenvironment interactions remain poorly characterized. Patients and methods The primary genomic cohort comprised 153 treatment-naïve patients with six cancer types, stratified...
S. Yajima, Y. Tsukada, Y. Sota et al.· Immuno-Oncology Technology· 0 citations
AIM
Standard treatment for muscle-invasive bladder cancer (MIBC) includes radical cystectomy (RC), a highly invasive procedure. We evaluated the utility of the Geriatric-8 (G8) screening tool in guiding treatment and whether the survival benefit of RC differs by G8 score.
METHODS
We retrospectively reviewed patients...
G. Okumura, S. Yajima, Erika Ikezoe et al.· Journal of Surgical Oncology· 0 citations
Circulating tumor DNA (ctDNA) increasingly guides adjuvant therapy and surveillance in urothelial carcinoma (UC), yet whether its prognostic effect is adequately summarized by a single pooled hazard ratio (HR), which assumes proportional hazards (PH), has not been formally evaluated. We searched five sources for studie...
S. Yajima, G. Okumura, Soichiro Yoshida et al.· Critical reviews in oncology...· 0 citations
It is proposed that the next phase of precision oncology should integrate the cellular dimension of metastasis through systematic circulating tumor cell (CTC) profiling and highlights adherent-to-suspension transition (AST) as one representative, experimentally tractable plasticity program that enables tumor cells to s...
T. Hashimoto, T. Shibuki, T. Fujisawa et al.· International Journal of Cli...· 0 citations
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