Author

S. Yamayoshi

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Open access Aug 2026

Characterisation of a human monoclonal antibody targeting a conserved epitope at the base of the HA head of influenza A(H3N2) virus

Summary Background Numerous broadly reactive human monoclonal antibodies (mAbs) against the haemagglutinin (HA) of influenza A viruses have recognised conserved epitopes across HA subtypes or within subtypes. Most heterosubtypic mAbs target the HA stem, the receptor-binding site (RBS), or the trimeric interface. Althou...

S. Yamayoshi, T. Hamabata, Yuka Inoue et al. · EBioMedicine · 0 citations

Open access Sep 2026

An endonuclease inhibitor unlocks the PA-X shutoff mechanism in influenza A virus.

It is revealed how PA-X modulates the cellular environment while sparing the viral genome to favor viral replication, and while PA-X targets a broad range of RNAs, viral RNAs are protected from its endonuclease activity through their assembly into vRNP complexes.

K. Oishi, Kaori Sano, S. Yamayoshi et al. · Cell Reports · 0 citations

Open access Aug 2026

Protective effect of A(H5N8) stockpiled vaccine against a virus genetically identical to a human isolate of bovine A(H5N1) influenza virus

It is demonstrated that the AS03-adjuvanted A(H5N8)-based stockpiled vaccine provides strong cross-protective efficacy against bovine A(H5N1) viruses during the early phase of a pandemic.

Ryuta Uraki, M. Kiso, Kiyoko Iwatsuki-Horimoto et al. · EBioMedicine · 0 citations