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Ibrutinib improved proliferative fitness, attenuated senescence-associated features and SASP output in paired patient and direct-exposure assays, and enhanced CAR T-cell expansion in an ibrutinib-resistant CLL model.
Findings define previously unrecognized interactions between CD38 and targetable pathways and genes in T-ALL and identify rational combinatorial strategies to enhance CD38-directed therapies and reduce relapse risk.
Collectively, epitope engineering of hematopoietic stem cells represents a versatile platform to expand the therapeutic window of precision immunotherapies and may enable safer, more effective combinatorial treatment strategies for both nonmalignant and malignant hematologic conditions.
A review of the biological rationale, delivery engineering, immunological barriers, CAR payload design, early clinical evidence, and future directions of this field focuses on the pharmacological principles that distinguish in vivo from ex vivo approaches and on the transformative potential for indications that lie bey...
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