Adenosine-to-inosine (A-to-I) RNA editing by ADAR1 is a key post-transcriptional modification, and mutations in ADAR1 lead to Aicardi-Goutières syndrome (AGS), an autoimmune disorder. Despite its biological and clinical relevance, the regulation of ADAR1 activity remains incompletely understood. Using a combination of...
Francisco Antonio Venegas Solis, Mengsi Lu, Roni Cohen-Fultheim et al.· RNA: A publication of the RN...· 0 citations
Eukaryotic mRNAs carry a 5′-terminal 7-methylguanosine (m7G) cap that is recognized by multiple cellular proteins and is essential for mRNA self-discrimination, stability, and translation. The eukaryotic translation initiation factor 4E (eIF4E) binds the 5′ cap and promotes recruitment of mRNAs to the ribosomal transla...
Sabine Schneider, Sarah Moreno, Moritz Thran et al.· bioRxiv· 0 citations
Selective modification of methylated bases in RNA and DNA is central to the field of epigenetics and furthermore fundamental for developing next-generation sequencing and liquid biopsy applications. While in DNA the detection and modification of 5-methylcytidine (5mdC) is fairly advanced, current strategies for detecti...
Kora Holschbach, T. Walter, Davide Guglielminotti et al.· RSC Chemical Biology· 0 citations
Current strategies for detecting and mapping RNA modifications in the small RNome include demodification-based sequencing approaches for heavily modified RNAs, targeted chemical and enzymatic methods for site-specific mapping, and emerging direct RNA sequencing technologies that allow analysis of native molecules witho...
Bennett Henzeler, Kathrin Halter, Özge Simsir et al.· Biological chemistry· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
