Author

Sabrina Heide

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Open access Sep 2026

Coordinated neural progenitor adaptations contribute to primate neocortical downscaling

Here, coordinated adaptations in NPC biology that bias neurodevelopmental trajectories toward neocortical downscaling are identified and multiple adaptations in apical and basal progenitors that converge on reduced progenitor capacity, alter early progenitor dynamics, and likely constrain neuronal output are uncovered.

Lidiia Tynianskaia, Cesar Mateo Bastidas-Betancourt, Esther Marie Grewe et al. · Science Advances · 0 citations

Open access Jul 2026

Comparative primate transcriptomics identifies a ZNF90–OVOL2 regulatory axis shaping human neural progenitor cell dynamics

This analysis identified two zinc-finger transcription factors for functional investigation: the ape-specific ZNF90 and the highly conserved OVOL2 and uncovered a previously uncharacterized regulatory axis with divergent but partially overlapping effects that converge on apical progenitor (AP) maintenance.

Cesar Mateo Bastidas-Betancourt, Maria Isabella Negretti-Ingravallo, İrfan Burak Göloğlu et al. · bioRxiv · 0 citations