Introduction Cinacalcet (CINA), a Biopharmaceutics Classification System (BCS) Class IV drug, exhibits limited oral bioavailability due to poor aqueous solubility and low intestinal permeability. We aimed to mechanistically enhance the oral bioavailability of CINA through the development of advanced hybrid-stabilized n...
Rawan Gamal Eldin, Salma M. Mosleh, O. Saher et al.· Frontiers in Pharmacology· 2 citations
Overall, natural products represent promising candidates for managing neurogenesis and neuroplasticity in AD, although further clinical studies are required to validate their therapeutic efficacy.
A. Shaheen, Mou-Sa A. Mai, Merhan O. Hindam et al.· Frontiers in Pharmacology· 2 citations
The kidney plays a critical role in metabolite excretion, fluid regulation, and homeostasis, yet remains highly vulnerable to structural and functional disorders. Kidney diseases represent a major global health burden, often progressing to chronic complications due to the limited efficacy and poor selectivity of conven...
Sadek Ahmed, Rana M. ElBishbishy, Mohamed A. Sadek et al.· Journal of Pharmacy & Pharma...· 4 citations
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