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Author

Safa Ghaziasgar

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Open access Sep 2026

AMPKα regulates glycolytic reprogramming to sustain NK cell proliferation and effector function

Natural killer (NK) cells are critical innate lymphocytes that mediate early anti-viral immunity through cytotoxicity and cytokine production. Activation of NK cells require metabolic reprogramming to sustain proliferation and effector functions; however, the molecular regulators coordinating this process remain inco...

A. Khan, Jannat Pervin, Safa Ghaziasgar et al. · 0 citations
Jul 2026

BCMA-CAR Natural Killer Cells Suppress Myeloma in Bone Marrow but Allow Emergence of Extramedullary Disease 2266680

This study showcases α-BCMA-CAR-IL15 NK cell therapy as a potent anti-MM therapeutic, achieving sustained MM elimination from the bone marrow and greatly extending survival in a MM-xenograft model, however, α-BCMA-CAR-IL15 NK cells appeared ineffective at eliminating extramedullary disease.

Seung-Hwan Lee, Shelby Kaczmarek, Safa Ghaziasgar et al. · 0 citations

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