Review
Aug 2026
AEG-1/MTDH: A central regulator of tumor progression, metabolic adaptation, and therapeutic resistance in gliomas.
Astrocyte-elevated gene-1 (AEG-1), also known as metadherin (MTDH), is a pleiotropic oncogene critically involved in the onset and development of glioblastoma (GBM), other malignant gliomas, and neuroblastoma. Its expression is upregulated under hypoxic conditions and during glucose deprivation, enabling tumor cells to...
S. Mohammad, A. Vasudevan, M. Al-Khreisat et al.
· Tissue & Cell · 0 citations