Modulation of NF-κB in Tuberculosis - Understanding Host-Pathogen Interactions and Therapeutic Opportunities.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb), remains a major global health challenge and a leading cause of infectious mortality. Central to TB pathogenesis is the nuclear factor-kappa B (NF-κB) signaling network, a master regulator of inflammation, immune activation, and host defense. This review h...