Molecular Basis for Uracil-DNA-Glycosylase to Identify DNA Damage in the Nucleosome.
The DNA base-excision repair (BER) pathway is initiated by a glycosylase, such as uracil-DNA-glycosylase (UDG), which identifies and removes a wrong base incorporated in the DNA sequence. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chain, and become e...