Review
Open access
Sep 2026
Purine nucleoside phosphorylase in breast cancer from metabolic regulation to targeted therapy: challenges and opportunities.
The rational design of selective inhibitors with improved pharmacokinetic profiles, combined with biomarker-driven patient stratification and combination therapy strategies, establishes a strong rationale for the development of clinically effective PNP-targeted therapies for breast cancer.
Sahar Salem, R. Hamdy, Sarra B. Shakartalla et al.
· RSC Medicinal Chemistry · 0 citations