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Review Open access Oct 2026

Beyond Nucleosome Assembly - Chromatin Assembly Factor 1 as a Nexus of Genome Stability Cell Identity and Cancer

Chromatin assembly factor 1 (CAF-1) is an evolutionarily conserved histone chaperone complex that deposits newly synthesized histones H3-H4 onto nascent DNA. By coupling DNA synthesis to nucleosome assembly, CAF-1 restores chromatin after replication and repair, supports epigenetic inheritance, and helps maintain cellu...

Sai Wu, Xiao-Qi Liu · 0 citations

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