Berbamine Alleviates Chronic Inflammatory Pain via Microglial Inhibition and Oxidative Stress Reduction in the Anterior Cingulate Cortex.
Chronic pain, defined as persistent pain lasting beyond three months, imposes a severe burden on patient quality of life. Berbamine (BBM), a natural bisbenzylisoquinoline alkaloid with anti-inflammatory and antioxidant properties, is a promising candidate for pain management, although its analgesic mechanism remains un...