Deciphering competing reaction pathways in the α-C–H functionalization of unprotected alicyclic amines via ketone-mediated hydride transfer
Alicyclic amines are pervasive in pharmaceuticals and natural products, yet direct α-C–H functionalization of unprotected secondary amines remains a long-standing challenge. Building on the historical oxidation of lithium amides by ketones, we present a combined experimental and computational study that establishes the...