Author

Saleh Alquethamy

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Open access Aug 2026

The intrinsically disordered AR2 domain of RNase E binds mRNA translation initiation regions

Intrinsically disordered regions are widespread in RNA-processing machines. In Escherichia coli, RNase E uses its intrinsically disordered C-terminal domain (CTD) to recruit RNAs to the N-terminal catalytic domain, including mRNAs targeted by regulatory small RNAs (sRNAs), but the basis of substrate recognition and spe...

Daniel G. Mediati, Saleh Alquethamy, Christopher Jin et al. · bioRxiv · 2 citations

Open access Aug 2026

Molecular Determinants of Functional Bacterial sRNA–mRNA Interactions Revealed by Integrating RNA Interactomes and Interpretable Machine Learning

Findings indicate that the regulatory fate of an sRNA–mRNA interaction is an emergent property of its biophysical context and protein-binding environment, rather than a direct consequence of physical pairing alone.

F. Safari, Daniel G. Mediati, Saleh Alquethamy et al. · bioRxiv · 0 citations