Author

Sally Negm

2 papers indexed here

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Review Sep 2026

The podocyte contactome in lupus nephritis: Current evidence and a framework for disease progression.

Lupus nephritis (LN) is initiated by immune-complex deposition, complement activation, and inflammation, but these mechanisms do not fully explain why some glomerular lesions resolve whereas others progress to podocyte depletion, glomerulosclerosis, and fibrosis. We present a conceptual spatial framework in which grade...

R. S. Hamad, Elsayed A. Elmorsy, A. El-kott et al. · Tissue & Cell · 0 citations

Review Sep 2026

Biophysical and molecular mechanisms of lysosomal mechanoresilience: Membrane tension, TMEM63A, and cellular injury.

Lysosomal membrane failure contributes to cellular injury by disrupting degradation, metabolism, immune signaling, and compartmental integrity, yet the physical principles that determine whether a mechanically loaded lysosome adapts or ruptures remain incompletely resolved. This review integrates biophysical and molecu...

R. S. Hamad, A. El-kott, Sally Negm et al. · Progress in Biophysics and M... · 0 citations